Dodgers?complete four-game sweep in Philly

Associated Press Sports

updated 4:02 p.m. ET June 7, 2012

PHILADELPHIA (AP) - Aaron Harang got his 100th career victory as Los Angeles overcame a two-run, sixth-inning deficit, and the Dodgers won 8-3 Thursday to complete their first four-game sweep at the Philadelphia Phillies in 66 years.

Harang (5-3) allowed three runs and eight hits in six innings, improving to 100-98 in 11 big league seasons. The Dodgers had not swept a four-game series at Philadelphia since Brooklyn accomplished the feat from May 24-26, 1946, according to STATS LLC.

Cole Hamels (8-3) led by three runs early and 3-1 in the sixth when he walked Elian Herrera leading off. Juan Rivera singled and, one out later, James Loney singled to cut the deficit to one. Tony Gwynn Jr.'s single tied the score, and Matt Treanor's single on a broken-bat flare to left put Los Angeles ahead 4-3.

Philadelphia has lost a season-high six straight and has the NL's worst home record at 12-19.

Hamels, who had been 3-0 with a 1.18 ERA against the Dodgers in his career, gave up four runs - three earned - and six hits in six innings with six strikeouts and a walk.

Los Angeles added four runs in the ninth against Chad Qualls. Herrera hit an RBI grounder with the bases loaded that second baseman Mike Fontenot booted for one of Philadelphia's three errors. Andre Ethier stopped an 0-for-16 slide with a two-run double, and Jerry Hairston Jr. followed with an RBI single.

Philadelphia took a 3-0 lead in the third following throwing errors by Alex Castellanos in right and Herrera at third. Hunter Pence hit an RBI grounder as Herrera threw wildly to the plate, Ty Wigginton had a sacrifice fly and Mike Fontenot a run-scoring bloop single.

Wigginton, starting at third base in place of injured Placido Polanco, misplayed consecutive grounders by Herrera and Juan Rivera starting the fourth, leading to Hairston's sacrifice fly.

NOTES: The Phillies recalled INF-OF Michael Martinez from Lehigh Valley to fill the roster spot vacated when 2B Freddy Galvis was placed on the 15-day disabled list with a lower-back strain. ... The Phillies open interleague play Friday night in Baltimore, with Joe Blanton (4-6) opposing Jake Arrieta (2-7). ... The Dodgers send Nathan Eovaldi (0-2) to the mound Friday night in Seattle, against the Mariners' Kevin Millwood (3-5). ... The Phils announced that retired catcher Mike Lieberthal will be added to the team's Wall of Fame during ceremonies before the Aug. 10 game against St. Louis. ... The announced attendance was 44.096, the Phils' 235th consecutive regular-season sellout. ... Paula Abdul danced with the Phillie Phanatic on the field after the fifth inning.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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CSN: Roy Halladay talks about the process of recovering from his injury over the next 6-8 weeks, and his desire to finish his career in Philly.

Tigers?top Indians, avoid sweep

DETROIT (AP) - Miguel Cabrera homered, Brennan Boesch broke out of a slump with a pair of hits and Casey Crosby earned his first major league win, helping the Detroit Tigers beat the Cleveland Indians 7-5 Thursday.

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1 million billion billion billion billion billion billion: Number of undiscovered drugs

[ Back to EurekAlert! ] Public release date: 6-Jun-2012
[ | E-mail | Share Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

A new voyage into "chemical space" occupied not by stars and planets but substances that could become useful in everyday life has concluded that scientists have synthesized barely one tenth of 1 percent of the potential medicines that could be made. The report, in the journal ACS Chemical Neuroscience, estimates that the actual number of these so-called "small molecules" could be 1 novemdecillion (that's 1 with 60 zeroes), 1 million billion billion billion billion billion billion, which is more than some estimates of the number of stars in the universe.

Jean-Louis Reymond and Mahendra Awale explain that small molecules, which are able to cross cell walls and interact with biological molecules in the body, are prime targets for scientists who develop new medicines. Most existing medications are small molecules. The authors focused on the "chemical space" inhabited by all of the small molecules that could possibly exist according to the laws of physics and chemistry. Researchers have identified millions of these compounds the ACS' Chemical Abstracts Service database contains almost 67 million substances. Reymond and Awale estimate that the molecules synthesized and tested as potential drugs so far represent less than 0.1 percent of chemical space. To aid researchers looking for new ways to prevent and treat disease, they set out to find the best ways to search for new small molecules.

The authors discuss several ways of getting a handle on chemical space, including by the size, shape and makeup of molecules. They show how computers can help researchers efficiently narrow a search for a new drug candidate. Computer modeling of chemical interactions can help researchers find a handful of promising molecules to synthesize and test in the lab. "Small molecule drugs are essential to the success of modern medicine," the authors note, and suggest that their methods may be particularly useful for finding new pharmaceuticals that target the central nervous system.

###

The authors acknowledge funding from the University of Berne, the Swiss National Science Foundation and the NCCR TransCure.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.



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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 6-Jun-2012
[ | E-mail | Share Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

A new voyage into "chemical space" occupied not by stars and planets but substances that could become useful in everyday life has concluded that scientists have synthesized barely one tenth of 1 percent of the potential medicines that could be made. The report, in the journal ACS Chemical Neuroscience, estimates that the actual number of these so-called "small molecules" could be 1 novemdecillion (that's 1 with 60 zeroes), 1 million billion billion billion billion billion billion, which is more than some estimates of the number of stars in the universe.

Jean-Louis Reymond and Mahendra Awale explain that small molecules, which are able to cross cell walls and interact with biological molecules in the body, are prime targets for scientists who develop new medicines. Most existing medications are small molecules. The authors focused on the "chemical space" inhabited by all of the small molecules that could possibly exist according to the laws of physics and chemistry. Researchers have identified millions of these compounds the ACS' Chemical Abstracts Service database contains almost 67 million substances. Reymond and Awale estimate that the molecules synthesized and tested as potential drugs so far represent less than 0.1 percent of chemical space. To aid researchers looking for new ways to prevent and treat disease, they set out to find the best ways to search for new small molecules.

The authors discuss several ways of getting a handle on chemical space, including by the size, shape and makeup of molecules. They show how computers can help researchers efficiently narrow a search for a new drug candidate. Computer modeling of chemical interactions can help researchers find a handful of promising molecules to synthesize and test in the lab. "Small molecule drugs are essential to the success of modern medicine," the authors note, and suggest that their methods may be particularly useful for finding new pharmaceuticals that target the central nervous system.

###

The authors acknowledge funding from the University of Berne, the Swiss National Science Foundation and the NCCR TransCure.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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CellBazaar : RealEstate Land Personal : INDUSTRIAL LAND

Category RealEstate Land Personal

Tk. 75,000,000, per Unit

Location Gazipur


Summary
30 Bigha available, Beside 35ft road at Shofipur, Gazipur
Details
30 Bigha land, Good for Heavy Industry or farming house, Now it is Tree garden. 35ft road has gone middle side of this land. 300 meter from Sofipur ansar academy 3rd gate and highway road. Only real buyer please contact shetedotnet@yahoo.com.cn
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HTC says cuts Q2 sales target by 13.3 percent

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Suu Kyi welcomes Australia easing Myanmar sanctions

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Horse racing panel to hear comments on drugs ? Artesia News

FRANKFORT, Ky. (AP) ? The Kentucky Horse Racing Commission will meet Tuesday afternoon to hear public comments on a proposal to phase out the use of an anti-bleeding drug on race days.

Kentucky would become the first to take the action against the drug, which is banned internationally.

The ban would initially apply to 2-year-olds, starting next January, and then to 2- and 3-year-olds starting the following year. In 2015, the ban would apply to any horse.

The meeting is set for 1 p.m. to 4 p.m. EDT at the Capitol Annex in Frankfort.

Tags: Doping, Frankfort, Horse racing, Kentucky, North America, Sports, United States

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Voters wait out lines to cast Wis. recall ballots

Voters cast their ballots Tuesday, June 5, 2012, in Milwaukee. Wisconsin Republican Gov. Scott Walker is taking on Democratic challenger Tom Barrett in a recall election. (AP Photo/Jeffrey Phelps)

Voters cast their ballots Tuesday, June 5, 2012, in Milwaukee. Wisconsin Republican Gov. Scott Walker is taking on Democratic challenger Tom Barrett in a recall election. (AP Photo/Jeffrey Phelps)

Wisconsin Democratic gubernatorial candidate Tom Barrett signs his name to get his ballot Tuesday, June 5, 2012, in Milwaukee. Barrett is facing Republican Wisconsin Gov. Scott Walker in a recall election. (AP Photo/Jeffrey Phelps)

Stickers are given to voters Tuesday, June 5, 2012, in Milwaukee. Wisconsin Republican Gov. Scott Walker is taking on Democratic challenger Tom Barrett in a recall election. (AP Photo/Jeffrey Phelps)

A woman casts her ballot Tuesday, June 5, 2012, in Milwaukee. Wisconsin Republican Gov. Scott Walker is taking on Democratic challenger Tom Barrett in a recall election. (AP Photo/Jeffrey Phelps)

A woman with her children cast her ballot Tuesday, June 5, 2012, in Milwaukee. Wisconsin Republican Gov. Scott Walker is taking on Democratic challenger Tom Barrett in a recall election. (AP Photo/Jeffrey Phelps)

(AP) ? The passions that fueled a long fight over union rights and Wisconsin's cash-strapped budget brought voters out in strong numbers Tuesday to decide whether to recall Gov. Scott Walker.

The first-term Republican was back on the ballot just a year and a half after his election. Enraged Democrats and labor activists gathered more than 900,000 signatures to force the vote after they failed to stop Walker and his GOP allies in the state Legislature from stripping most public employees of their collective bargaining rights.

Walker faced a rematch with his opponent from the 2010 race, Democratic Milwaukee Mayor Tom Barrett, who lost by nearly 6 percentage points. If he succeeds, Walker would become the first U.S. governor to successfully fend off a recall.

The recall effort began bubbling last year, shortly after the former Milwaukee County executive successfully pushed through the union rights law that also required most state workers to pay more for health insurance and pension benefits.

"I think most people are just happy to have the election over," Walker said at a suburban Milwaukee elementary school where he cast his ballot. "I think most voters of the state want to have all the attack ads off. They want to have their TVs back. They want to have their lives back."

Barrett, meanwhile, applauded voters for turning out in force and for being prepared to wait a while to cast their ballots.

"Obviously the lines are very, very long, which we take as a very encouraging sign. People are engaged in this," Barrett said, adding that the energy around the state the past four days has been "building and building."

Turnout was strong across the state. There were lines at multiple polling places, but no major problems were reported. Anyone in line after polls close at 8 p.m. can still cast a ballot, said Reid Magney, spokesman for the state Government Accountability Board.

Turnout was on pace to meet predictions of 65 percent of eligible voters, Magney said. That type of turnout is more typically seen in a presidential race.

Jeff Naunheim, a warranty analyst from St. Francis who voted for Walker, called the recall a waste of time and money. But Barrett supporter Lisa Switzter of Sun Prairie said even if the recall doesn't go Barrett's way, "it proves a point."

"People in Wisconsin aren't just going to stand by and let a governor take over the state and cut social services," said Switzer, an occupational therapist and single mother on BadgerCare, the state's health insurance program for the working poor.

Preliminary exit polls conducted for The Associated Press suggested the public's views on collective bargaining are deeply entrenched. About three quarters either strongly approve or strongly disapprove of the changes for government workers. Overall voters were about evenly divided on the question, with about half approving and half disapproving of those changes.

And most voters made up their minds about the candidates before the final ballots were even set. About 9 in 10 who participated in early exit polling said they decided before May.

Both sides hoped for strong support from their bases: Madison and Milwaukee for Democrats, suburban Milwaukee counties and the Fox Valley around Green Bay for Republicans. Other more divided parts of the state, like along the western border and south of Milwaukee in the Racine area, could determine the race.

Walker stands in unique company: He is only the third governor in U.S. history to face a recall vote. The other two lost, most recently California Gov. Gray Davis in 2003.

Walker, the 44-year-old son of a minister, has remained unflappable throughout the campaign. Along the way, he's become a star among Republicans and the most successful fundraiser in Wisconsin politics, collecting at least $31 million from around the country since taking office. That obliterated his fundraising record of $11 million from 2010.

Walker and Republicans outspent Barrett and Democrats $47 million to $19 million, based on the most recent tally by the government watchdog group the Wisconsin Democracy Campaign.

The governor wasn't the only politician up for recall. His lieutenant governor, Rebecca Kleefisch, and three Republican state senators also faced votes, and a fourth state Senate seat will be determined after the Republican incumbent resigned rather than face the recall.

Tuesday's vote also will have implications for labor unions and the presidential election in November. Unions have a lot at stake because they pushed so hard to force a recall.

Implications for the presidential race were less clear, but President Obama did not campaign for Barrett. Instead, the president weighed in through social media, tweeting his support for Barrett. His campaign emailed supporters, urging them to back the Milwaukee mayor. But the White House cautioned against drawing any national conclusions from the recall's outcome.

"A race where one side is outspending the other by at least a ratio of 8-to-1 probably won't tell us much about a future race," White House press secretary Jay Carney said Tuesday.

Republicans are hopeful a Walker victory would pave the way for Mitt Romney to win Wisconsin, making him the first GOP candidate to carry the state since Ronald Reagan in 1984. If Walker loses, most agree Obama will have an edge. Either way, the state is likely to remain in play.

___

Associated Press writers Gretchen Ehlke and Marilynn Marchione in Milwaukee, Todd Richmond in Sun Prairie, Carrie Antlfinger in St. Francis and Jennifer Agiesta in Washington contributed to this report.

Associated Press

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Judge Says Pension Fund Can't Seek Bankruptcy Protection ? NPR ...

The Northern Mariana Islands: white sand, blue water, and huge pension liabilities. ctsnow/Flickr

The Northern Mariana Islands: white sand, blue water, and huge pension liabilities.

Earlier this year, the pension plan of a U.S. territory in the Pacific Ocean became the first pubic U.S. pension fund to file for bankruptcy. The fund ? for the Commonwealth of the Northern Mariana Islands ? had been in financial trouble for years, largely because the government of the islands hadn?t kept up with the payments it was required to make into the fund.

The legal case hinged on a single important question: Is a pension fund separate from the government or part of it? Under U.S bankruptcy law, commonwealths and states themselves cannot file for bankruptcy.

The CNMI may be small, but this case has ramifications for much larger pension funds all across the U.S. that are facing shortfalls.

As law professor David Skeel told us recently, this case could set a key precedent for other funds.

?

?Folks who do not want pension funds to be able to file for bankruptcy or to restructure are probably watching with terror, ? said Skeel. ?Folks who think there is no alternative but to figure out a way to restructure the pension I think are watching to see if this is another avenue.?

Right now, it looks like this other avenue is blocked. A U.S. bankruptcy judge in Hawaii has issued a tentative ruling to dismiss the case.

The judge wrote that the Northern Mariana Islands Retirement Fund is ?a ?governmental unit?? and therefore ?not eligible for relief under chapter 11 of the Bankruptcy Code.?

But what he said after that is intriguing. He took time in his ruling to defend the trustees of the Fund for pursuing this route:

The trustees of the Fund should be praised, not criticized, for commencing this case. The trustees find themselves in an intolerable position. The Fund for which they are responsible is caught between an irresistible force ? obligations to retirees which it cannot pay ? and an immovable object ? the government, which has persistently failed to pay its debt to the Fund. The trustees? attempt to find a solution to this dilemma is creative and praiseworthy even though I am inclined to rule that it cannot succeed. Congress did not intend that the Bankruptcy Code could solve all problems, least of all the financial problems of governmental units.

The attorney for the fund, Brad Huesman, told the local paper, the Saipan Tribune, that the fund hasn?t decided whether or not it will appeal the ruling. He says the pension fund is weighing its options.

One option that is reportedly being discussed is dissolving the fund and having the CNMI Department of Finance take over responsibility for paying out the benefits. The Fund?s administrator, Richard S. Villagomez, hates that idea.

?Having the Fund?s assets under the control of the entity that owes it the most money and is responsible for remitting contributions is analogous to the ?fox guarding the henhouse,? ? Villagomez told the Marianas Variety.

This new option ? the government of the CNMI taking over the fund ? could foreshadow what may happen to other struggling pension funds here in the continental U.S.

Dick Ingram, executive director of the Illinois Teachers Retirement System, recently told us if his pension fund ran out of money, it would just become part of the state. That?s similar to what?s being proposed in the CNMI.

?The state law says the state has to pay the benefits if we can?t, so at that point we become just an administrator and send them the payroll and they pay it, ? said Ingram.

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Study reports seizure-freedom in 68 percent of juvenile myoclonic epilepsy patients

[ Back to EurekAlert! ] Public release date: 6-Jun-2012
[ | E-mail | Share Share ]

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell

Seizure severity and antiepileptic drug polytherapy among predictors of poor seizure outcomes

A 25-year follow-up study reveals that 68% of patients with juvenile myoclonic epilepsy (JME) became seizure-free, with nearly 30% no longer needing antiepileptic drug (AED) treatment. Findings published today in Epilepsia, a journal of the International League Against Epilepsy (ILAE), report that the occurrence of generalized tonic-clonic seizures preceded by bilateral myoclonic seizures, and AED polytherapy significantly predicted poor long-term seizure outcome.

Patients with JME experience "jerking" of the arms, shoulders, and sometimes the legs. Previous evidence suggests that JME is a common type of epilepsy (in up to 11% of people with epilepsy), occurring more frequently in females than in males, and with onset typically in adolescence.. There is still much debate among experts over the long-term outcome of JME, and about which factors predict seizure outcome.

To further investigate JME outcomes and predictive factors, Dr. Felix Schneider and colleagues from the Epilepsy Center at the University of Greifswald in Germany studied data from 12 male and 19 female patients with JME. All participants had a minimum of 25 years follow-up which included review of medical records, and telephone or in-person interviews.

Sixty-eight percent of the 31 JME patients became free of seizures, and 28% discontinued AED treatment due to seizure-freedom. Significant predictors of poor long-term seizure outcome included: occurrence of generalized tonic-clonic seizures (GTCS - formerly known as grand mal seizures) that affect the entire brain and which are preceded by bilateral myoclonic seizures (abnormal movements on both sides of the body and a regimen of AED polytherapy.

Researchers also determined that remission of GTCS using AED therapy significantly increased the possibility of complete seizure-freedom. However, once AED therapy is discontinued, the occurrence of photoparoxysmal responses (brain discharges in response to brief flashes of light) significantly predicted an increased risk of seizure recurrence.

"Our findings confirm the feasibility of personalized treatment of the individual JME patient," concludes Dr. Schneider. "Life-long AED therapy is not necessarily required in many patients to maintain seizure freedom. Understanding the predictors for successful long-term seizure outcome will aid clinicians in their treatment options for those with JME."

###

This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact healthnews@wiley.com.

Full citation:"Predictors for Long-Term Seizure Outcome in Juvenile Myoclonic Epilepsy: 25-63 Years Of Follow-Up." Julia Geithner, Felix Schneider, Zhong Wang, Julia Berneiser, Rosemarie Herzer, Christof Kessler and Uwe Runge. Epilepsia; Published Online: June 6, 2012 (DOI: 10.1111/j.1528-1167.2012.03526.x).

URL upon publication: http://doi.wiley.com/10.1111/j.1528-1167.2012.03526.x

Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.

The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.


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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell

Seizure severity and antiepileptic drug polytherapy among predictors of poor seizure outcomes

A 25-year follow-up study reveals that 68% of patients with juvenile myoclonic epilepsy (JME) became seizure-free, with nearly 30% no longer needing antiepileptic drug (AED) treatment. Findings published today in Epilepsia, a journal of the International League Against Epilepsy (ILAE), report that the occurrence of generalized tonic-clonic seizures preceded by bilateral myoclonic seizures, and AED polytherapy significantly predicted poor long-term seizure outcome.

Patients with JME experience "jerking" of the arms, shoulders, and sometimes the legs. Previous evidence suggests that JME is a common type of epilepsy (in up to 11% of people with epilepsy), occurring more frequently in females than in males, and with onset typically in adolescence.. There is still much debate among experts over the long-term outcome of JME, and about which factors predict seizure outcome.

To further investigate JME outcomes and predictive factors, Dr. Felix Schneider and colleagues from the Epilepsy Center at the University of Greifswald in Germany studied data from 12 male and 19 female patients with JME. All participants had a minimum of 25 years follow-up which included review of medical records, and telephone or in-person interviews.

Sixty-eight percent of the 31 JME patients became free of seizures, and 28% discontinued AED treatment due to seizure-freedom. Significant predictors of poor long-term seizure outcome included: occurrence of generalized tonic-clonic seizures (GTCS - formerly known as grand mal seizures) that affect the entire brain and which are preceded by bilateral myoclonic seizures (abnormal movements on both sides of the body and a regimen of AED polytherapy.

Researchers also determined that remission of GTCS using AED therapy significantly increased the possibility of complete seizure-freedom. However, once AED therapy is discontinued, the occurrence of photoparoxysmal responses (brain discharges in response to brief flashes of light) significantly predicted an increased risk of seizure recurrence.

"Our findings confirm the feasibility of personalized treatment of the individual JME patient," concludes Dr. Schneider. "Life-long AED therapy is not necessarily required in many patients to maintain seizure freedom. Understanding the predictors for successful long-term seizure outcome will aid clinicians in their treatment options for those with JME."

###

This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact healthnews@wiley.com.

Full citation:"Predictors for Long-Term Seizure Outcome in Juvenile Myoclonic Epilepsy: 25-63 Years Of Follow-Up." Julia Geithner, Felix Schneider, Zhong Wang, Julia Berneiser, Rosemarie Herzer, Christof Kessler and Uwe Runge. Epilepsia; Published Online: June 6, 2012 (DOI: 10.1111/j.1528-1167.2012.03526.x).

URL upon publication: http://doi.wiley.com/10.1111/j.1528-1167.2012.03526.x

Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.

The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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EU, Germany exploring Spanish rescue

MADRID/BERLIN (Reuters) - Germany and European Union officials are urgently exploring ways to rescue Spain's debt-stricken banks although Madrid has not yet requested assistance and is resisting political conditions, several EU sources said on Wednesday.

Madrid, the euro zone's fourth biggest economy, said on Tuesday it was effectively losing access to credit markets due to prohibitive borrowing costs and appealed to European partners to help revive its banks.

But Economy Minister Luis de Guindos said after talks at the European Commission on Wednesday there were no immediate plans to apply for a bailout.

Spain would await the results of an IMF report and an independent audit of the banking sector, both due this month, before taking decisions on how to recapitalize the banks, he said.

Sources familiar with discussions in Berlin and Brussels said intensive contingency planning was already under way for EU aid. Lawyers are examining the fine print of European treaties to see how Madrid could get money from the euro zone's rescue funds without the stigma of a full economic adjustment program, they said.

European shares and the euro rose and safe haven German bond futures fell as investors positioned themselves for a possible surprise move by the European Central Bank to ease monetary policy at its monthly meeting on Wednesday.

A run of grim economic data and rising tension in financial markets over Spain's fragile banks and Greece's uncertain euro zone future has led markets to price in an outside chance that the ECB will lower rates.

Sources in Berlin said the German Finance Ministry believes the euro zone's permanent rescue fund, the 500-billion-euro ($625 billion) European Stability Mechanism, due to enter into force next month, could lend directly to Spain's FROB bank rescue fund. EU lawyers are not convinced this would be legal.

One advantage would be that smaller euro zone countries such as the Netherlands or Finland could not hold up a loan since approval by the ESM board does not require unanimity.

A series of reforms to Spain's financial system have failed to persuade investors that huge losses from a 2008 property market crash have been fully addressed, and doubts about the cost of a final rescue have deepened the euro zone debt crisis.

Finance chiefs of the Group of Seven major economies, afraid of a possible run on Spanish banks, held urgent but inconclusive talks on the European situation on Tuesday.

"The market's expectation regarding further policy action globally is picking up," said Ian Stannard, an executive director at Morgan Stanley.

Underlining the dangers to the entire 17-nation zone of inaction, Moody's Investors Service cut the credit ratings of several German and Austrian banks, citing the greater risk of further shocks stemming from the region's debt crisis. Germany is the single currency's strongest economy.

Spain is the latest member of the euro area under pressure to accept international aid following financial rescues of Greece, Ireland and Portugal in the two-year debt crisis.

The premium investors demand to hold its 10-year debt over the German equivalent hit a euro era high last week on concerns it will eventually have to accept a Greek-style bailout.

In the first public German pressure for Spain to apply for a bailout, the parliamentary floor leader of Chancellor Angela Merkel's conservatives said: "I think Spain needs to come under the rescue umbrella, not because of the country (the state budget) but because of its banks.

Volker Kauder, who is close to Merkel, told ARD television he did not believe Madrid could receive direct aid for its banks from the euro zone rescue fund and insisted that assistance to the state would entail the usual policy conditions.

"RUNNING OUT OF RUNWAY"

The U.S. Treasury, which chaired the G7 phone hook-up, said in a statement that the group's finance chiefs had discussed "progress towards a financial and fiscal union in Europe" and agreed to monitor developments closely. But the group made no joint statement and took no immediate steps.

Japanese Finance Minister Jun Azumi added that major economies needed to ease market fears and referred to a G20 meeting in Mexico on June 18-19.

The G20 summit, to include both Japan and China, the world's top creditors, is shaping up as a key focus of global efforts to contain the euro zone crisis.

"We will cooperate and share responsibility to ease market worries through these meetings," Azumi told reporters.

The United States, which is pressuring European governments to take a bold step toward financial and fiscal union, would like to see the makings of a plan by the G20 summit.

U.S. President Barack Obama, whose re-election chances this year could be jeopardized by another global financial crisis, has been anxious not to be seen dictating to Europe.

But Canadian Prime Minister Stephen Harper was more forthright on Tuesday: "I don't want to sound too alarmist, but we are kind of running out of runway here," he said.

EU leaders meet on June 28-29 to discuss a strategy for overcoming the crisis, which began in late 2009 when Greece revealed it had covered up a huge budget deficit.

"It doesn't look like they have a quick fix at hand, not a fundamental game changer at this point in time," said Rainer Guntermann, strategist at Commerzbank in Frankfurt.

Longer term, European leaders have begun thinking seriously about the economic union needed to secure the single currency. But that end-game is still months or years away.

SPAIN TO TEST MARKET

Spain will test the market on Thursday by issuing up to 2 billion euros ($2.5 billion) in government bonds at auction.

The ECB has so far shunned calls to resume purchases of Spanish government bonds, and Germany has rejected allowing direct aid from the euro zone's rescue fund to recapitalize Spanish banks without setting conditions for the government.

Pressure is building on Germany, the biggest contributor to euro zone rescue funds, to work harder on fostering growth.

Berlin argues it is already doing its share by encouraging generous domestic wage settlements, accepting the prospect of higher-than-usual German inflation and most recently agreeing that Spain should have more time to achieve its fiscal targets.

Chancellor Angela Merkel opened the door on Monday to the prospect of a euro zone banking union in the medium term, saying she would consider the idea of putting systemically important cross-border banks under European supervision.

However, Berlin is so far resisting a joint deposit guarantee for euro zone banks and a bank resolution fund, both of which would create new liabilities for German taxpayers.

(Additional reporting by Noah Barkin and Andreas Rinke in Berlin, Stella Dawson and Matt Spetalnik in Washington, Fiona Ortiz in Madrid. Writing by Paul Taylor)

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